Ziomara Gerdtzen Hakim

Ziomara Gerdtzen Hakim

  • Grado máximo: Ph.D. Ingeniería Química (2005), University of Minnesota
  • Jerarquía: Profesor Asistente
  • Área de investigación: Cultivo Celular, Redes Metabólicas, Modelamiento de Sistemas Biológicos
  • Email: zgerdtze@ing.uchile.cl


  1. A. Colins, Z.P. Gerdtzen, M.T. Nuñez y J.C. Salgado, (2017) “Mathematical Modeling of Intestinal Iron Absorption using Genetic Programming”, PLoS ONE 12(1) e0169601 .ISSN: 1932-6203, FI: 3.057

  2. A. Esparza, Z.P. Gerdtzen, A. Olivera-Nappa, J.C. Salgado y M.T. Núñez, (2015) “Iron-Induced Reactive Oxygen Species Mediate Transporter DMT1 Endocytosis and Iron uptake in Intestinal Epithelial Cells”, American Journal of Physiology – Cell Physiology, 309(8) C558-C567. ISSN: 0363-6143, FI: 3.395.

  3. G. Zapata-Torres, A. Fierro, G. Barriga-González, J.C. Salgado y C. Celis-Barros, (2015) “Revealing Monoamine Oxidase B Catalytic Mechanisms by Means of the Quantum Chemical Cluster Approach”, Journal of Chemical Information and Modeling, 55(7) 1349-1360. ISSN: 1549-9596, FI: 3.657

  4. Wilkens, C. A, Gerdtzen, Z. P., (2015) “Comparative Metabolic Analysis of CHO Cell Clones Obtained through Cell Engineering, for IgG Productivity, Growth and Cell Longevity” PLoS ONE 10(3): e0119053. ISSN: 1932-6203.

  5. Castro, J. F., Razmilic, V., Gerdtzen, Z. P., 2013, Genome based metabolic flux analysis of Ethanoligenens harbinense for enhancedhydrogen production. International Journal of Hydrogen Energy 38(3):1297-1306.

  6. Gerdtzen, Z. P., 2012, Modeling Metabolic Networks for Mammalian Cell Systems: General Considerations, Modeling Strategies, and Available Tools, Advances in Biochemical Engineering/Biotechnology,127:71-108.

  7. Flores, K. A., Salgado, J. C.,Zapata-Torres, G., Gerdtzen, Z. P., Gonzalez, M. J., Hermoso, M. A. 2012 “Effect of the electrostatic potential on the internalization mechanism of cell penetrating peptides derived from TIRAP”. Biotechnology and Bioprocess Engineering, 17, 485-499.

  8. Gerdtzen, Z. P.2011 “Modeling Metabolic Networks for Mammalian Cell Systems: General Considerations, Modeling Strategies, and Available Tools”. Adv. Biochem Eng Biotechnol.1-38, DOI: 10.1007/10_2011_120, (2011).

  9. Wilkens, C. A., Altamirano, C., Gerdtzen, Z. P. 2011 “Comparative Metabolic Analysisis of Lactate for CHO cells in Glucose and Galactose”. Biotechnology and Bioprocess Engineering 16:714-724. DOI 10.1007/s12257-010-0409-0.

  10. Martinez, V., Gerdtzen, Z. P., Andrews, B.A., Asenjo, J.A. 2010 “Viral vectors for the treatment of alcoholism; use of metabolic Flux Analysis for cell cultivation and vector production”. Metabolic Engineering, 12(2):129-37.

  11. Salgado, J. C., Olivera, A., Gerdtzen, Z. P., Tapia, V. , Conca, C., Nunez, M. T. 2010 “Mathematical Modeling of the Dynamic Storage of Iron in Ferritin”. BMC Systems Biology Nov 3;4-147.

  12. Yee, J. C., Gerdtzen, Z. P., Hu, W. S. 2009 “Comparative Transcriptome Analysis to Unveil Genes Affecting Recombinant Protein Productivity”. Biotechnology and Bioengineering 102(1):246-63.

  13. Gerdtzen, Z. P., Salgado, J. C., Osses, A., Asenjo, J. A., Rapaport, I., Andrews, B. A. 2009 “Modeling heterocyst pattern formation in cyanobacteria”. BMC Bioinformatics 10(S6):S16.

  14. Quintanilla, M.E., Tampier, L., Sapag, A., Gerdtzen, Z. P., Israel, Y. 2007 “Gender, alcohol dehydrogenase, acetaldehyde burst and aversion to ethanol in the rat: a systems perspective”. Am J. Physiol Endocrinol Metab., 293: 531-537.

  15. Martinez, V., Gerdtzen, Z. P., Asenjo, J. A., Andrews, B. A. 2007 “Media optimization and metabolic flux analysis of HEK293 cells for adenovirus production”. Journal of Biotechnology 131(2):S201-S202.


  1. 2014 – 2019: Financiamiento Basal de Centros Científicos y Tecnológicos de Excelencia para la creación del CENTRO DE BIOTECNOLOGIA Y BIOINGENIERÍA.Comisión Nacional de lnvestigación Cientifica y Técnológica CONICYT. Investigador

  2. 2013 – 2016: FONDECYT 1130317: “A systems biology approach for studying and understanding cellular processes involved in the regulation of intestinal iron absorption”. Co-investigador.

  3. 2009 – 2011: Proyecto FONDECYT Nº 11090268. “Optimization of antibody production in CHO cells through metabolic engineering and media design”. Investigador Principal.

  4. 2006 – 2009: INI 06/04-2. “Caracterización de los parámetros de cultivo para células animales, optimización, modelamiento y análisis genómico contextualizado”. Investigador Principal.

  5. 2006 – 2008: Proyecto FONDECYT Nº 1061119. “Metabolic engineering for the optimization of metabolism in yeast and mammalian cells: Mathematical modeling and genomic studies”. Co-investigador.